Our Research Projects
The Liu Lab is dedicated to studying the fundamental innate immune sensing mechanisms and their interplay with viral pathogens. We leverage state-of-the-art experimental approaches that combine genome-wide phenotypic screens, reverse genetics, and animal models to dissect the host-virus interface on a molecular level. Our ultimate goal is to achieve bench-to-bedside translation of innovative antiviral therapies and vaccines.
Our research is three-pronged:
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Innate immune sensing and regulatory mechanisms
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ISG15 modulation of cellular responses and its perturbation by viral pathogens
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Effector-triggered immunity and viral antagonisms
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RNA virus biology
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Mechanisms of influenza A virus and coronavirus replication and pathogenicity
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Host determinants of abortive viral replication
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Respiratory RNA virus attenuation and vaccine design​
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Viral genome remodelling and mechanisms of virus attenuation​
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T-cell targeted influenza and coronavirus vaccines
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