Recent Research

Liu, G.*, & Gack, M. U.* (2023). An optimized circular polymerase extension reaction-based method for functional analysis of SARS-CoV-2. Virology Journal, 20(1), 1-9. *Co-corresponding author

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Serman, T., Chiang, C., Liu, G., Sayyad, Z., Pandey, S., Volcic, M., ... & Gack, M. U. (2023). Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication. Cell Host & Microbe, 31(8), 1317-1330.

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Afsar, M., Liu, G., Jia, L., Ruben, E. A., Nayak, D., Sayyad, Z., ... & Olsen, S. K. (2023). Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nature Communications, 14(1), 4786.

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Khan, D., Terenzi, F., Liu, G., Ghosh, P. K., Ye, F., Nguyen, K., ... & Fox, P. L. (2023). A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon. Nature Communications, 14(1), 3385.

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Chen, D. Y.†, Chin, C. V.†, Kenney, D., Tavares, A. H., Khan, N., Conway, H. L., Liu, G., ... & Saeed, M. (2023). Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation. Nature, 615(7950), 143-150.

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Naesens, L.†, Muppala, S.†, Acharya, D., Nemegeer, J., Bogaert, D., Lee, J. H., ... & Haerynck, F. (2022). GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141. Science Immunology, 7(77), eabq4531.

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Acharya, D., Reis, R.†, Volcic, M.†, Liu, G., Wang, M. K., Chia, B. S., ... & Gack, M. U. (2022). Actin cytoskeleton remodeling primes RIG-I-like receptor activation. Cell, 185(19), 3588-3602.

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Mou, H.†, Quinlan, B. D.†, Peng, H.†, Liu, G., Guo, Y., Peng, S., ... & Farzan, M. (2021). Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2. PLoS Pathogens, 17(4), e1009501.

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Liu, G.†, Lee, J. H.†, Parker, Z. M., Acharya, D., Chiang, J. J., van Gent, M., ... & Gack, M. U. (2021). ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. Nature Microbiology, 6(4), 467-478.

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Riedl, W., Acharya, D., Lee, J. H., Liu, G., Serman, T., Chiang, C., ... & Gack, M. U. (2019). Zika virus NS3 mimics a cellular 14-3-3-binding motif to antagonize RIG-I-and MDA5-mediated innate immunity. Cell Host & Microbe, 26(4), 493-503.

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Liu, G., Lu, Y., Liu, Q., & Zhou, Y. (2019). Inhibition of ongoing influenza A virus replication reveals different mechanisms of RIG-I activation. Journal of Virology, 93(6), 10-1128.

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Liu, G., Lu, Y., Thulasi Raman, S. N., Xu, F., Wu, Q., Li, Z., ... & Zhou, Y. (2018). Nuclear-resident RIG-I senses viral replication inducing antiviral immunity. Nature Communications, 9(1), 3199.

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Park, H. S., Liu, G., Thulasi Raman, S. N., Landreth, S. L., Liu, Q., & Zhou, Y. (2018). NS1 protein of 2009 pandemic influenza A virus inhibits porcine NLRP3 inflammasome-mediated interleukin-1 beta production by suppressing ASC ubiquitination. Journal of Virology, 92(8), e00022-18.

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Thulasi Raman, S. N., Liu, G., Pyo, H. M., Cui, Y. C., Xu, F., Ayalew, L. E., ... & Zhou, Y. (2016). DDX3 interacts with influenza A virus NS1 and NP proteins and exerts antiviral function through regulation of stress granule formation. Journal of Virology, 90(7), 3661-3675.

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Liu, G., Park, H. S., Pyo, H. M., Liu, Q., & Zhou, Y. (2015). Influenza A virus panhandle structure is directly involved in RIG-I activation and interferon induction. Journal of Virology, 89(11), 6067-6079.

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Review and Commentary Articles

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Sarkar, L.†, Liu, G.†, & Gack, M. U. (2023). ISG15: its roles in SARS-CoV-2 and other viral infections. Trends in Microbiology, 31(12):1262-1275 (†equal contribution)

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Liu, G., & Gack, M. U. (2022). Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus. Current Opinion in Immunology, 102252.

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Liu, G., & Gack, M. U. (2022). SARS-CoV-2 learned the ‘Alpha’bet of immune evasion. Nature Immunology, 23(3), 351-353.

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Liu, G., & Gack, M. U. (2020). Distinct and orchestrated functions of RNA sensors in innate immunity. Immunity, 53(1), 26-42.

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Acharya, D.†, Liu, G.†, & Gack, M. U. (2020). Dysregulation of type I interferon responses in COVID-19. Nature Reviews Immunology, 20(7), 397-398. (†equal contribution)

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Liu, G., & Zhou, Y. (2019). Cytoplasm and beyond: dynamic innate immune sensing of influenza A virus by RIG-I. Journal of Virology, 93(8), 10-1128.

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