The Liu Lab - Understanding Virus-Host Interactions

The GuanQun Leo Liu Lab at McGill University is dedicated to unravelling the complex interactions between respiratory RNA viruses and host cells. Our team of researchers is committed to advancing the understanding of RNA virus biology and its interplay with host antiviral immunity.

Our Research Focus

At The Liu Lab, we delve into the fundamental innate immune sensing mechanisms and their interplay with viral pathogens. We use RIG-I-like receptors and respiratory RNA viruses, particularly influenza A virus and coronaviruses, as models to discover new players in pattern recognition and regulation of antiviral innate immunity. With a multidisciplinary approach, we aim to pave the way for innovative antiviral strategies and therapeutics.

Featured Publications

An optimized circular polymerase extension reaction-based method for functional analysis of SARS-CoV-2

We report an optimized CPER methodology for reverse genetics engineering of SARS-CoV-2, which resulted in more rapid virus rescue and efficient viral yields.